Biomedical Genomics Core Services

Churchill

Advancing sequencing technologies make genomic medicine and population scale whole genome sequencing studies a possibility. However, current strategies for analysis of this data rely upon parallelization approaches that have limited scalability, lack reproducibility and are complex to implement, requiring substantial investment in specialized IT solutions.

To overcome these challenges we developed Churchill, a highly accurate and deterministic analysis solution, which fully automates the analytical process required to perform the complex and computationally intensive process of alignment, post-alignment processing, local realignment, recalibration and genotyping. Our balanced regional parallelization strategy enables division of each analysis step across multiple compute instances, enabling whole genome variant discovery and genotyping via local re-assembly of haplotypes to be completed in minutes. For whole genome sequencing, the entire analysis process from FASTQ to high confidence variant calls can be completed in as little as 90 minutes.

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